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Open Access Review

Evaluation of current methods to detect the mutations of epidermal growth factor receptor in non-small cell lung cancer patients

Jasmina Obradovic1 and Vladimir Jurisic2*

Author Affiliations

1 Institute of Biology and Ecology, Faculty of Science, University of Kragujevac, Radoja Domanovica 12, 34000, Kragujevac, Serbia

2 Faculty of Medicine, University of Kragujevac, Svetozara Markovica 69, 34 000, Kragujevac, Serbia

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Multidisciplinary Respiratory Medicine 2012, 7:52  doi:10.1186/2049-6958-7-52

Published: 11 December 2012

Abstract

Many different methods were developed to detect commonly known mutations and to screen new mutations of the epidermal growth factor receptor in non-small cell lung cancer patients. Some of these methods are so sensitive as to be able to detect even one epidermal growth factor receptor mutant tumor cell among up to 1000–2000 normal cells. We have considered current methods chronologically reported to detect mutations in epidermal growth factor receptor in patients with non-small cell lung cancer. We also gave a short preview of their significance for routine clinical works. A Pub Med literature search was performed in order to demonstrate what methods are mostly used in mutation detection and to show their distribution through the last 10 years.

Keywords:
EGFR; Methods; Mutations; NSCLC