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Open Access Original research article

The relationship between C-reactive protein and prognostic factors in chronic obstructive pulmonary disease

Reshu Agarwal1, Mohammad Shoaib Zaheer1, Zubair Ahmad2 and Jamal Akhtar2*

Author Affiliations

1 Department of Medicine, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh 202002, India

2 Department of Tuberculosis & Respiratory Diseases, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh 202002, India

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Multidisciplinary Respiratory Medicine 2013, 8:63  doi:10.1186/2049-6958-8-63

Published: 28 September 2013

Abstract

Background

The purpose of the study was to determine the relationship between high sensitivity C-reactive protein (hs-CRP) levels and prognostic factors in chronic obstructive pulmonary disease.

Methods

We studied 50 stable COPD patients with: spirometry, 6 minute walk distance, body mass index, GOLD stage (spirometric classification) and smoking status. In these patients hs-CRP values were measured and compared with those of 50 healthy controls. Then the serum hs-CRP was subjected to evaluation for any correlation with the predictors of outcomes in COPD subjects.

Results

Hs-CRP levels were higher in COPD patients than in controls (4.82 vs. 0.88 mg/L p < 0.01). Correlation was found between hs-CRP and the following variables: FEV1 (r= −0.813; p < 0.01), 6MWD (r= −0.876; p < 0.01), body mass index (r= −0.710; p < 0.01), GOLD stage (r= 0.797, p < 0.01) and smoking status (r= 0.796; p < 0.01). Using multivariate analysis, FEV1 and 6MWD showed the strongest negative association with hs-CRP levels.

Conclusions

The circulating levels of the inflammatory marker hs-CRP are significantly elevated in patients with COPD, supporting the view that COPD is in part an inflammatory disorder. Hs-CRP levels in stable COPD patients are best correlated with FEV1 and 6-minute walk distance (6MWD). This information should be considered when hs-CRP levels are measured in stable COPD patients.

Keywords:
High sensitivity-C-reactive protein; Chronic obstructive pulmonary disease